fibroblast growth factor receptor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9030	SU4984		FGFR , IGF-1R , PDGFR
	SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).		FGFR , IGF-1R , PDGFR
T5466	Tyrosine kinase-IN-1		VEGFR , FGFR , FLT , PDGFR
	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）		VEGFR , FGFR , FLT , PDGFR
T6996	SU 5402	SU5402	VEGFR , FGFR , PDGFR
	SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.		VEGFR , FGFR , PDGFR
T2642	PD173074		Apoptosis , EGFR , VEGFR , FGFR , IGF-1R , Src
	PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for FGFR1 than PDGFR and c-Src.		Apoptosis , EGFR , VEGFR , FGFR , IGF-1R , Src
T3466	FIIN-3		EGFR , FGFR
	FIIN-3 is an irreversible inhibitor of FGFR.		EGFR , FGFR
T6082	SSR128129E	SSR	FGFR
	SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs.		FGFR
T1777	Nintedanib	BIBF 1120,Intedanib	VEGFR , FGFR , FLT , PDGFR , Src
	Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM). Nintedanib has an...		VEGFR , FGFR , FLT , PDGFR , Src
T0097L	Pazopanib	GW786034	VEGFR , FGFR , PDGFR , c-Kit , Autophagy
	Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits VEGFR-1, -2 and -3, c-kit and PDGF-R, which may result i...		VEGFR , FGFR , PDGFR , c-Kit , Autophagy
T4425	JK-P3		VEGFR
	JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube format...		VEGFR
T2347	BLU9931		FGFR
	BLU9931 is the first selective small molecule inhibitor of FGFR4.		FGFR
T6836	FIIN-2		FGFR
	FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.		FGFR
T8976	PD-089828		EGFR , FGFR , PDGFR , Src
	PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 ...		EGFR , FGFR , PDGFR , Src
T1948	AZD4547		VEGFR , FGFR
	AZD4547, a new-type specific FGFR inhibitor, targets for FGFR1/2/3 (IC50: 0.2/2.5/1.8 nM in cell-free assays).		VEGFR , FGFR
T7611	ODM-203		VEGFR , FGFR
	ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity		VEGFR , FGFR
T15185	Lucitanib	E-3810	VEGFR , FGFR
	Lucitanib (E-3810) is a novel VEGFR and FGFR inhibitor. It potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 (IC50s: 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively).		VEGFR , FGFR
T23127	PD-161570	PD 161570	EGFR , FGFR , PDGFR , Src
	PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, a...		EGFR , FGFR , PDGFR , Src
TQ0256	FGFR4-IN-1		FGFR
	FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).		FGFR
T0520	Lenvatinib	E7080	VEGFR , FGFR , c-RET , PDGFR , c-Kit
	Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity. Lenvatinib has the strongest inhibitory activity on VEGFR2 and VEGFR3 (...		VEGFR , FGFR , c-RET , PDGFR , c-Kit
T2358	ENMD-2076		Apoptosis , VEGFR , FGFR , FLT , c-RET , PDGFR , Src , Aurora Kinase
	ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
TQ0317	R1530	R-1530,R 1530	VEGFR , FGFR , FLT , PDGFR
	R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.		VEGFR , FGFR , FLT , PDGFR